BIOL122 Biology|First-pass Metabolism

Question 1 (5 marks) Based on the description above  Select/name one of the diseases/conditions Mary-Lou is suffering from and describe two signs and/or symptoms from Mary-Lou’s history that support your selection.  Explain the pathophysiology of the condition you named Question 2 (3 marks) Explain the mechanism of action of one drug type Mary-Lou is prescribed with and describe how these drug actions help mitigate some of her symptoms. In you answer, make references to the pathophysiology of the relevant disease and relate the chosen drug’s mechanism of action to the aetiology/pathogenesis of the disease. Question 3 (4 marks) The following questions relate to a drug called MedZ: a. MedZ contains 200 mg of the active ingredient in an intestine-solvent capsule. The active ingredient is effectively transported across the intestinal mucosa, which ensures that 78% of the drug is absorbed and enters the portal circulation. The drug undergoes a significant degree of first-pass metabolism, in which process 55% of the drug passing through the liver gets metabolized and therefore degraded to an inactive product. Calculate MedZ’s bioavailability and show your calculations
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