BIOC100 Basic Biology I : Common Inflammatory

Task:

Objective:
 
The aim of this study was to analyze lamin A/C mRNA levels in abdominal subcutaneous adipose tissue in 
two conditions—obesity and type 2 diabetes—that share common inflammatory and metabolic features, and to assess 
their relationship with selected inflammatory and adipogenic genes.
 
Methods and Procedures:
 
This is a cross-sectional study involving 52 nondiabetic and 54 type 2 diabetes patients. 
Anthropometrical and analytical measurements (glycemic, lipidic, and inflammatory profiles) were performed, and 
mRNA expression was determined using real-time PCR.
 
Results:
 
Lamin A and C isoforms are expressed differentially. Lamin A/C mRNA levels were increased in obese and 
in type 2 diabetes patients. We also observed a strong relationship between both isoforms (B = 2.218, P < 0.001) 
and among lamin C mRNA expression and adipogenic (sterol-responsive element binding protein-1 (SREBP1c)) and 
inflammatory (interleukin-6 (IL-6)) markers (B = 0.854, P = 0.001, and B = 0.557, P < 0.001, respectively).
Discussion: These data suggest that lamin A/C may be involved in the adipocyte gene profile observed in obesity and 
type 2 diabetes

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QUALITY: 100% ORIGINAL PAPER – NO PLAGIARISM – CUSTOM PAPER

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